All trans-Retinal ( Retinaldehyde | Vitamin A aldehyde )

产品货号. M19986 CAS No. 116-31-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

All trans-Retinal
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

全反式视网膜是视网膜中主要的维生素A代谢物之一。在生理条件下，全反式 RAL 再生为视觉发色团 11-顺式视黄醛。
产品描述

All-trans-retinal is a one of the major vitamin A metabolites in the retina. In physiological conditions all-trans-RAL is regenerated to the visual chromophore 11-cis-retinal.
体外实验

Cell Viability AssayCell Line:ARPE-19 cells Concentration:10 μM, 20 μM, 30 μM Incubation Time:16 h Result:Displayed a dose-dependent toxicity which included the morphological disruption of ARPE-19 cells.Western Blot Analysis Cell Line:ARPE-19 cells Concentration:10 μM, 30 μM Incubation Time:30 min Result:The phosphorylation of p53 at Ser 46 were detected prior to Bax activation in ARPE-19 cells.
体内实验

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同义词

Retinaldehyde | Vitamin A aldehyde
通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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1.Sawada O et al. All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. Exp Eye Res. 2014 Jun;123:27-36.

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